Vitamin D and Parkinson’s Disease

Parkinson’s disease is a neurodegenerative disorder affecting movement and sometimes memory and thinking abilities. Deep brain stimulation is a surgical treatment that may improve movement in patients with Parkinson’s disease. Could vitamin D influence Parkinson’s disease together with deep brain stimulation? A study published earlier this year (link to the study) attempted to answer this.

๐—•๐—ฒ๐—ณ๐—ผ๐—ฟ๐—ฒ ๐˜„๐—ฒ ๐—ท๐˜‚๐—บ๐—ฝ ๐—ถ๐—ป๐˜๐—ผ ๐˜๐—ต๐—ฒ ๐—ฑ๐—ฒ๐˜๐—ฎ๐—ถ๐—น๐˜€, ๐—ต๐—ฒ๐—ฟ๐—ฒ ๐—ถ๐˜€ ๐˜€๐—ผ๐—บ๐—ฒ ๐—ฏ๐—ฎ๐—ฐ๐—ธ๐—ด๐—ฟ๐—ผ๐˜‚๐—ป๐—ฑ ๐—ถ๐—ป๐—ณ๐—ผ๐—ฟ๐—บ๐—ฎ๐˜๐—ถ๐—ผ๐—ป:

โ€ข Vitamin D is essential for different body processes, such as immune system function and bone health.
โ€ข Evidence shows that vitamin D levels tend to be lower in patients with Parkinson’s disease.
โ€ข Since our bodies produce vitamin D mainly through sunlight exposure, the study aimed to supplement vitamin D during the autumn-winter months to minimise any effects from sunlight exposure in the northern hemisphere (the study took place in Poland). We can also obtain vitamin D from natural sources such as fatty fish and egg yolk, or fortified foods.
โ€ข In this study, patients with Parkinson’s disease undergoing deep brain stimulation were divided into two groups: one group was supplemented with vitamin D, and the other received a placebo (no therapeutic effect).

๐—ช๐—ต๐—ฎ๐˜ ๐˜๐—ต๐—ฒ ๐—ฆ๐˜๐˜‚๐—ฑ๐˜† ๐—™๐—ผ๐˜‚๐—ป๐—ฑ:

โ€ข Vitamin D seemed to reduce blood levels of TNF-ฮฑ, an inflammation marker.
โ€ข The placebo group showed a rise in 3-hydroxykyneurine (3-HK), a substance that might harm the brain. Meanwhile, the vitamin D group showed more stable levels of 3-HK and possibly increased levels of protective substances like kynurenic acid (KYNA).
โ€ข A link between vitamin D and 3-HK levels suggests vitamin D might offer some protection to the brain.

๐—›๐—ผ๐˜„ ๐——๐—ผ๐—ฒ๐˜€ ๐—ง๐—ต๐—ถ๐˜€ ๐—–๐—ผ๐—ป๐—ป๐—ฒ๐—ฐ๐˜ ๐˜๐—ผ ๐—•๐—ฟ๐—ฎ๐—ถ๐—ป ๐—›๐—ฒ๐—ฎ๐—น๐˜๐—ต:

Vitamin D might protect against brain inflammation in Parkinson’s patients undergoing deep brain stimulation, potentially benefiting their brain health.

๐—Ÿ๐—ผ๐—ผ๐—ธ๐—ถ๐—ป๐—ด ๐—”๐—ต๐—ฒ๐—ฎ๐—ฑ:

These encouraging findings are specific to a subset of Parkinson’s patients, those undergoing deep brain stimulation. Moreover, this study took place only in one country. More research will expand on the potential role of vitamin D in neurodegenerative diseases.

Above all, vitamin D is essential to maintain our general health due to its potential role in different body functions. In the UK, it is recommended to take 10 micrograms/day of vitamin D during the autumn and winter months.

๐—–๐—ผ๐—ป๐˜€๐—ถ๐—ฑ๐—ฒ๐—ฟ๐—ถ๐—ป๐—ด ๐—ถ๐˜๐˜€ ๐—ฝ๐—ผ๐˜๐—ฒ๐—ป๐˜๐—ถ๐—ฎ๐—น ๐—ฟ๐—ผ๐—น๐—ฒ๐˜€, ๐—ต๐—ผ๐˜„ ๐—ฑ๐—ผ ๐˜†๐—ผ๐˜‚ ๐—ด๐—ฒ๐˜ ๐˜ƒ๐—ถ๐˜๐—ฎ๐—บ๐—ถ๐—ป ๐——? ๐Ÿง ๐Ÿฅ—

(Image created with Canva Pro)