Peer-Reviewed Publications

1. Lin Z, Kim E, Ahmed M, Han G, Simmons C, Redhead Y, Bartlett J, Pena Altamira LE, Callaghan I, White MA, Singh N, Sawiak S, Spires-Jones T, Vernon AC, Coleman MP, Green J, Henstridge C, Davies JS, Cash D, Sreedharan J. MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in amyotrophic lateral sclerosis-frontotemporal dementia. Brain Commun. 2021;3(2):fcab114. doi: 10.1093/braincomms/fcab114. eCollection 2021. PubMed PMID: 34136812; PubMed Central PMCID: PMC8204366.

2. Petralla S, Parenti C, Ravaioli V, Fancello I, Massenzio F, Virgili M, Monti B, Pena-Altamira E. Dietary Protein Source Influences Brain Inflammation and Memory in a Male Senescence-Accelerated Mouse Model of Dementia. Mol Neurobiol. 2021 Apr;58(4):1312-1329. doi: 10.1007/s12035-020-02191-y. Epub 2020 Nov 9. PubMed PMID: 33169333.

3. White MA, Lin Z, Kim E, Henstridge CM, Pena Altamira E, Hunt CK, Burchill E, Callaghan I, Loreto A, Brown-Wright H, Mead R, Simmons C, Cash D, Coleman MP, Sreedharan J. Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss. Acta Neuropathol Commun. 2019 Oct 28;7(1):166. doi: 10.1186/s40478-019-0800-9. PubMed PMID: 31661035; PubMed Central PMCID: PMC6819591.

4. Petralla S, Peña-Altamira LE, Poeta E, Massenzio F, Virgili M, Barile SN, Sbano L, Profilo E, Corricelli M, Danese A, Giorgi C, Ostan R, Capri M, Pinton P, Palmieri F, Lasorsa FM, Monti B. Deficiency of Mitochondrial Aspartate-Glutamate Carrier 1 Leads to Oligodendrocyte Precursor Cell Proliferation Defects Both In Vitro and In Vivo. Int J Mol Sci. 2019 Sep 11;20(18). doi: 10.3390/ijms20184486. PubMed PMID: 31514314; PubMed Central PMCID: PMC6769484.

5. Uliassi E, Peña-Altamira LE, Morales AV, Massenzio F, Petralla S, Rossi M, Roberti M, Martinez Gonzalez L, Martinez A, Monti B, Bolognesi ML. A Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential. ACS Chem Neurosci. 2019 Jan 16;10(1):279-294. doi: 10.1021/acschemneuro.8b00242. Epub 2018 Oct 9. PubMed PMID: 30253086.

6. Massenzio F, Peña-Altamira E, Petralla S, Virgili M, Zuccheri G, Miti A, Polazzi E, Mengoni I, Piffaretti D, Monti B. Microglial overexpression of fALS-linked mutant SOD1 induces SOD1 processing impairment, activation and neurotoxicity and is counteracted by the autophagy inducer trehalose. Biochim Biophys Acta Mol Basis Dis. 2018 Dec;1864(12):3771-3785. doi: 10.1016/j.bbadis.2018.10.013. Epub 2018 Oct 10. PubMed PMID: 30315929.

7. Peña-Altamira LE, Polazzi E, Giuliani P, Beraudi A, Massenzio F, Mengoni I, Poli A, Zuccarini M, Ciccarelli R, Di Iorio P, Virgili M, Monti B, Caciagli F. Release of soluble and vesicular purine nucleoside phosphorylase from rat astrocytes and microglia induced by pro-inflammatory stimulation with extracellular ATP via P2X7 receptors. Neurochem Int. 2018 May;115:37-49. doi: 10.1016/j.neuint.2017.10.010. Epub 2017 Oct 20. PubMed PMID: 29061383.

8. Roldán-Peña JM, Alejandre-Ramos D, López Ó, Maya I, Lagunes I, Padrón JM, Peña-Altamira LE, Bartolini M, Monti B, Bolognesi ML, Fernández-Bolaños JG. New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer’s and antiproliferative agents. Eur J Med Chem. 2017 Sep 29;138:761-773. doi: 10.1016/j.ejmech.2017.06.048. Epub 2017 Jun 27. PubMed PMID: 28728108.

9. Peña-Altamira E, Petralla S, Massenzio F, Virgili M, Bolognesi ML, Monti B. Nutritional and Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging and Alzheimer’s Disease. Front Aging Neurosci. 2017;9:175. doi: 10.3389/fnagi.2017.00175. eCollection 2017. Review. PubMed PMID: 28638339; PubMed Central PMCID: PMC5461295.

10. Profilo E, Peña-Altamira LE, Corricelli M, Castegna A, Danese A, Agrimi G, Petralla S, Giannuzzi G, Porcelli V, Sbano L, Viscomi C, Massenzio F, Palmieri EM, Giorgi C, Fiermonte G, Virgili M, Palmieri L, Zeviani M, Pinton P, Monti B, Palmieri F, Lasorsa FM. Down-regulation of the mitochondrial aspartate-glutamate carrier isoform 1 AGC1 inhibits proliferation and N-acetylaspartate synthesis in Neuro2A cells. Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1422-1435. doi: 10.1016/j.bbadis.2017.02.022. Epub 2017 Feb 21. PubMed PMID: 28235644.

11. Giuliani P, Zuccarini M, Buccella S, Peña-Altamira LE, Polazzi E, Virgili M, Monti B, Poli A, Rathbone MP, Di Iorio P, Ciccarelli R, Caciagli F. Evidence for purine nucleoside phosphorylase (PNP) release from rat C6 glioma cells. J Neurochem. 2017 Apr;141(2):208-221. doi: 10.1111/jnc.14004. PubMed PMID: 28251649.

12. Jeřábek J, Uliassi E, Guidotti L, Korábečný J, Soukup O, Sepsova V, Hrabinova M, Kuča K, Bartolini M, Peña-Altamira LE, Petralla S, Monti B, Roberti M, Bolognesi ML. Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer’s disease. Eur J Med Chem. 2017 Feb 15;127:250-262. doi: 10.1016/j.ejmech.2016.12.048. Epub 2016 Dec 26. PubMed PMID: 28064079.

13. Contestabile A, Peña-Altamira E, Virgili M, Monti B. Zinc supplementation in rats impairs hippocampal-dependent memory consolidation and dampens post-traumatic recollection of stressful event. Eur Neuropsychopharmacol. 2016 Jun;26(6):1070-82. doi: 10.1016/j.euroneuro.2015.12.041. Epub 2016 Jan 7. PubMed PMID: 26774280.

14.  Peña-Altamira E, Prati F, Massenzio F, Virgili M, Contestabile A, Bolognesi ML, Monti B. Changing paradigm to target microglia in neurodegenerative diseases: from anti-inflammatory strategy to active immunomodulation. Expert Opin Ther Targets. 2016;20(5):627-40. doi: 10.1517/14728222.2016.1121237. Epub 2015 Dec 15. Review. PubMed PMID: 26568363.

15. Polazzi E, Mengoni I, Peña-Altamira E, Massenzio F, Virgili M, Petralla S, Monti B. Neuronal Regulation of Neuroprotective Microglial Apolipoprotein E Secretion in Rat In Vitro Models of Brain Pathophysiology. J Neuropathol Exp Neurol. 2015 Aug;74(8):818-34. doi: 10.1097/NEN.0000000000000222. PubMed PMID: 26185969.

16. Nepovimova E, Uliassi E, Korabecny J, Peña-Altamira LE, Samez S, Pesaresi A, Garcia GE, Bartolini M, Andrisano V, Bergamini C, Fato R, Lamba D, Roberti M, Kuca K, Monti B, Bolognesi ML. Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects. J Med Chem. 2014 Oct 23;57(20):8576-89. doi: 10.1021/jm5010804. Epub 2014 Oct 10. PubMed PMID: 25259726.

17. Peña-Altamira E, Polazzi E, Moretto E, Lauriola M, Monti B. The transcription factor CCAAT enhancer-binding protein β protects rat cerebellar granule neurons from apoptosis through its transcription-activating isoforms. Eur J Neurosci. 2014 Jan;39(2):176-85. doi: 10.1111/ejn.12407. Epub 2013 Nov 6. PubMed PMID: 24438488.

18. Botta A, Malena A, Tibaldi E, Rocchi L, Loro E, Pena E, Cenci L, Ambrosi E, Bellocchi MC, Pagano MA, Novelli G, Rossi G, Monaco HL, Gianazza E, Pantic B, Romeo V, Marin O, Brunati AM, Vergani L. MBNL142 and MBNL143 gene isoforms, overexpressed in DM1-patient muscle, encode for nuclear proteins interacting with Src family kinases. Cell Death Dis. 2013 Aug 15;4:e770. doi: 10.1038/cddis.2013.291. PubMed PMID: 23949219; PubMed Central PMCID: PMC3763452.

19. Peña-Altamira LE, Polazzi E, Monti B. Histone post-translational modifications in Huntington’s and Parkinson’s diseases. Curr Pharm Des. 2013;19(28):5085-92. doi: 10.2174/13816128113199990355. Review. PubMed PMID: 23448464.

20. Polazzi E, Mengoni I, Caprini M, Peña-Altamira E, Kurtys E, Monti B. Copper-zinc superoxide dismutase (SOD1) is released by microglial cells and confers neuroprotection against 6-OHDA neurotoxicity. Neurosignals. 2013;21(1-2):112-28. doi: 10.1159/000337115. Epub 2012 May 9. PubMed PMID: 22572742.

21. Giuliani P, Ballerini P, Ciccarelli R, Buccella S, Romano S, D’Alimonte I, Poli A, Beraudi A, Peña E, Jiang S, Rathbone MP, Caciagli F, Di Iorio P. Tissue distribution and metabolism of guanosine in rats following intraperitoneal injection. J Biol Regul Homeost Agents. 2012 Jan-Mar;26(1):51-65. PubMed PMID: 22475097.

22. D’Arrigo A, Colavito D, Peña-Altamira E, Fabris M, Dam M, Contestabile A, Leon A. Transcriptional profiling in the lumbar spinal cord of a mouse model of amyotrophic lateral sclerosis: a role for wild-type superoxide dismutase 1 in sporadic disease?. J Mol Neurosci. 2010 Jul;41(3):404-15. doi: 10.1007/s12031-010-9332-2. Epub 2010 Feb 23. PubMed PMID: 20177826.

23. Peña-Altamira E, Petazzi P, Contestabile A. Nitric oxide control of proliferation in nerve cells and in tumor cells of nervous origin. Curr Pharm Des. 2010;16(4):440-50. doi: 10.2174/138161210790232211. Review. PubMed PMID: 20236073.

24. Polazzi E, Altamira LE, Eleuteri S, Barbaro R, Casadio C, Contestabile A, Monti B. Neuroprotection of microglial conditioned medium on 6-hydroxydopamine-induced neuronal death: role of transforming growth factor beta-2. J Neurochem. 2009 Jul;110(2):545-56. doi: 10.1111/j.1471-4159.2009.06117.x. Epub 2009 Apr 27. PubMed PMID: 19457129.

25. Crochemore C, Virgili M, Bonamassa B, Canistro D, Pena-Altamira E, Paolini M, Contestabile A. Long-term dietary administration of valproic acid does not affect, while retinoic acid decreases, the lifespan of G93A mice, a model for amyotrophic lateral sclerosis. Muscle Nerve. 2009 Apr;39(4):548-52. doi: 10.1002/mus.21260. PubMed PMID: 19296491.

26. Virgili M, Crochemore C, Peña-Altamira E, Contestabile A. Regional and temporal alterations of ODC/polyamine system during ALS-like neurodegenerative motor syndrome in G93A transgenic mice. Neurochem Int. 2006 Feb;48(3):201-7. doi: 10.1016/j.neuint.2005.10.004. Epub 2005 Nov 14. PubMed PMID: 16290266.

27. Peña-Altamira E, Crochemore C, Virgili M, Contestabile A. Neurochemical correlates of differential neuroprotection by long-term dietary creatine supplementation. Brain Res. 2005 Oct 5;1058(1-2):183-8. doi: 10.1016/j.brainres.2005.07.011. Epub 2005 Sep 6. PubMed PMID: 16140286.

28. Crochemore C, Peña-Altamira E, Virgili M, Monti B, Contestabile A. Disease-related regressive alterations of forebrain cholinergic system in SOD1 mutant transgenic mice. Neurochem Int. 2005 Apr;46(5):357-68. doi: 10.1016/j.neuint.2004.12.004. PubMed PMID: 15737434.

Clinical Research, Public Health, Neuroscience and Nutrition